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Pracinostat

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Cat.No：IP1610 Solarbio

CAS：929016-96-6

Molecular Formula：C₂₀H₃₀N₄O₂

Molecular Weight：358.48

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to brown Solid

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Product Information

CAS	929016-96-6
Name	Pracinostat
Molecular Formula	C₂₀H₃₀N₄O₂
Molecular Weight	358.48
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to brown Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD17215206
SMILES	ONC(/C=C/C1=CC=C2N(C(CCCC)=NC2=C1)CCN(CC)CC)=O
Target Point	HDAC
Passage	DNA Damage/DNA Repair;Epigenetics;NF-κB
Background	Pracinostat is a potent histone deacetylase (HDAC) inhibitor.
Biological Activity	Pracinostat 是一种有效的组蛋白去乙酰化酶 (HDAC) 抑制剂，对 HDACs 的 IC50 值为 40-140 nM，可用于癌症研究。[1-3]
Data Literature Source	[1]. Novotny-Diermayr V，et al. SB939，a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer. Mol Cancer Ther. 2010 Mar;9(3):642-52. [2]. Wang H，et al. Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939)，an orally active histone deacetylase inhibitor with a superior preclinical profile. J Med Chem. 2011 Jul 14;54(13):4694-720. [3]. Novotny-Diermayr V，et al. The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML. Blood Cancer J. 2012 May;2(5):e69.
Unit	Bottle
Specification	5mg 10mg 25mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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