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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > PIK-93CAS：593960-11-3
Molecular Formula：C14H16ClN3O4S2
Molecular Weight：389.88
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 593960-11-3 |
| Name | PIK-93 |
| Molecular Formula | C14H16ClN3O4S2 |
| Molecular Weight | 389.88 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD12922510 |
| SMILES | CC(NC1=NC(C)=C(S1)C2=CC=C(C(S(=O)(NCCO)=O)=C2)Cl)=O |
| Target Point | PI4K |
| Passage | PI3K/Akt/mTOR |
| Background | PIK-93 is a potent PI4KIIIβ inhibitor. |
| Biological Activity | PIK-93 是一种合成的，有效的 PI4KIIIβ 抑制剂，IC50 值为 19 nM，同时可抑制 PI3Kγ和 PI3Kα 的活性，IC50 值分别为 16 nM 和 39 nM。[1-5] |
| IC50 | PI4KIIIβ:19nM;p110γ:16nM;PI3KC2β:140nM;DNA-PK:64nM;ATM:490nM;mTORC1:1.38μM;ATR:17μM [1-5] |
| Data Literature Source | [1]. Knight ZA，et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47. [2]. Van Keymeulen A，et al. To stabilize neutrophil polarity，PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J Cell Biol. 2006 Jul 31;174(3):437-45. [3]. Toth B，et al. Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi. J Biol Chem. 2006 Nov 24;281(47):36369-77. [4]. Monet M，et al. Involvement of phosphoinositide 3-kinase and PTEN protein in mechanism of activation of TRPC6 protein in vascular smooth muscle cells. J Biol Chem. 2012 May 18;287(21):17672-81. [5]. Arita M，et al. Phosphatidylinositol 4-kinase III beta is a target of enviroxime-like compounds for antipoliovirus activity. J Virol. 2011 Mar;85(5):2364-72. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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