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MC1568

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Cat.No：IM1240 Solarbio

CAS：852475-26-4

Molecular Formula：C₁₇H₁₅FN₂O₃

Molecular Weight：314.31

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

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Product Information

CAS	852475-26-4
Name	MC1568
Molecular Formula	C₁₇H₁₅FN₂O₃
Molecular Weight	314.31
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
SMILES	O=C(NO)/C=C/C1=CC=C(/C=C/C(C2=CC=CC(F)=C2)=O)N1C
Target Point	HDAC
Passage	DNA Damage/DNA Repair;Epigenetics;NF-κB
Background	MC1568 is an inhibitor of histone deacetylase (HDAC II).
Biological Activity	MC1568是组蛋白脱乙酰酶(HDAC II)的抑制剂，可用于癌症研究。[1-4]
Data Literature Source	[1]. Nebbioso A，et al. Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity ofHDAC-MEF2 complexes. EMBO Rep. 2009 Jul;10(7):776-82. [2]. Venza I，et al. Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells. Pigment Cell Melanoma Res. 2013 Mar;26(2):193-204. [3]. Nebbioso A，et al. HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation. J Mol Endocrinol. 2010 Oct;45(4):219-28. [4]. Kassis H，et al. Class IIa histone deacetylases affect neuronal remodeling and functional outcome after stroke. Neurochem Int. 2016 Jun;96:24-31.
Unit	Bottle
Specification	5mg 10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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