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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > LY2811376CAS：1194044-20-6
Molecular Formula：C15H14F2N4S
Molecular Weight：320.36
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to brown Solid
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| CAS | 1194044-20-6 |
| Name | LY2811376 |
| Molecular Formula | C15H14F2N4S |
| Molecular Weight | 320.36 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18074525 |
| SMILES | FC1=C(C2=CN=CN=C2)C=C([C@]3(C)CCSC(N3)=N)C(F)=C1 |
| Target Point | Beta-secretase |
| Passage | Neuronal Signaling |
| Background | LY2811376 is a beta-secretase (BACE1) inhibitor. |
| Biological Activity | LY2811376 是一种可口服的, 非肽段的 β-secretase (BACE1) 抑制剂, IC50 值为 239 nM-249 nM, 能够降低 Aβ 蛋白的分泌, EC50 值为 300 nM[1-4]。 |
| IC50 | IC50: 239-249nM (BACE1) EC50 值为 300nM[1-4] |
| Data Literature Source | [1]. May PC， et al. Robust central reduction of amyloid-β in humans with an orally available， non-peptidic β-secretase inhibitor. J Neurosci. 2011 Nov 16; 31 (46) :16507-16516. [2]. Zhang X， et al. Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2015 Aug 4; 112 (31) :9734-9. [3]. Ghosh AK， et al. Prospects of β-Secretase Inhibitors for the Treatment of Alzheimer's Disease. ChemMedChem. 2015 Sep; 10 (9) :1463-6. [4]. Filser S， et al. Pharmacological inhibition of BACE1 impairs synaptic plasticity and cognitive functions. Biol Psychiatry. 2015 Apr 15; 77 (8) :729-39 |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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