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Luminespib

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Cat.No：IL0750 Solarbio

CAS：747412-49-3

Molecular Formula：C₂₆H₃₁N₃O₅

Molecular Weight：465.54

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

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Product Information

CAS	747412-49-3
Name	Luminespib
Molecular Formula	C₂₆H₃₁N₃O₅
Molecular Weight	465.54
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD14635361
SMILES	O=C(C1=NOC(C2=CC(C(C)C)=C(O)C=C2O)=C1C3=CC=C(CN4CCOCC4)C=C3)NCC
Target Point	HSP90α；HSP90β
Passage	Cell Cycle;Metabolic Enzyme&Protease
Background	Luminespib is a potent HSP90 inhibitor.
Biological Activity	Luminespib (NVP-AUY922) 是有效的 HSP90 抑制剂，对HSP90β的IC50和Kis为21±16,8.2±0.7 nM，HSP90α的IC50和Kis为7.8±1.8,9.0±5.0 nM。 Luminespib对GRP94和TRAP-1的活性较弱，IC50分别为535±51 nM（Ki，108 nM）和85±8 nM（Ki，53 nM）。 [1-3]
Data Literature Source	[1]. Eccles，Suzanne A.，et al. NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth，Angiogenesis，and Metastasis. Cancer Research (2008)，68(8)，2850-2860. [2]. Best OG，et al. Heat shock protein-90 inhibitor，NVP-AUY922，is effective in combination with fludarabine against chronic lymphocytic leukemia cells cultured on CD40L-stromal layer and inhibits their activated/proliferative phenotype. Leuk Lymphoma. 2012 Jul 9. [3]. Moser C，et al. Stoeltzing O.Targeting HSP90 by the novel inhibitor NVP-AUY922 reduces growth and angiogenesis of pancreatic cancer. Anticancer Res. 2012 Jul;32(7):2551-61.
Unit	Bottle
Specification	10mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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