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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > MasitinibCAS：790299-79-5
Molecular Formula：C28H30N6OS
Molecular Weight：498.64
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to yellow Solid
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| CAS | 790299-79-5 |
| Name | Masitinib |
| Molecular Formula | C28H30N6OS |
| Molecular Weight | 498.64 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 226-164-5 |
| MDL | MFCD09954132 |
| SMILES | O=C(NC1=CC=C(C(NC2=NC(C3=CC=CN=C3)=CS2)=C1)C)C4=CC=C(CN5CCN(CC5)C)C=C4 |
| Target Point | PDGFR;c-Kit inhibitor |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | Masitinib is a Kit inhibitor. It also inhibits PDGFRα/β. |
| Biological Activity | Masitinib是一种Kit 抑制剂，IC50 为200 nM。 它也可抑制PDGFRα/β，IC50 为 540nM/800nM。Masitinib是一种竞争性ATP抑制剂，浓度≤500nM。 Masitinib还有效抑制重组PDGFR和细胞内激酶Lyn，并在较小程度上抑制成纤维细胞生长因子受体3.相反，Masitinib显示出对Abl和c-Fms的弱抑制。[1-4] |
| IC50 | 200nM(Kit)，540nM(PDGFRα)，800nM(PDGFRβ)[1-4] |
| Data Literature Source | [1]. Dubreuil P，et al. Masitinib (AB1010)，a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT. PLoS One，2009，4(9)，e7258. [2]. Lawrence J，et al. Masitinib demonstrates anti-proliferative and pro-apoptotic activity in primary and metastatic feline injection-site sarcoma cells. Vet Comp Oncol，2011，doi: 10.1111/j.1476-5829.2011.00291.x. [3]. Hahn KA，et al. Masitinib is safe and effective for the treatment of canine mast cell tumors. J Vet Intern Med，2008，22(6)，1301-1309. [4]. Humbert M，et al. Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model. PLoS One. 2010 Mar 4;5(3):e9430 |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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