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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > PD153035 HydrochlorideCAS：183322-45-4
Molecular Formula：C16H14BrN3O2·HCl
Molecular Weight：396.67
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 183322-45-4 |
| Name | PD153035 Hydrochloride |
| Molecular Formula | C16H14BrN3O2·HCl |
| Molecular Weight | 396.67 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD03490521 |
| SMILES | COC1=C(C=C(C2=C1)N=CN=C2NC3=CC(Br)=CC=C3)OC.Cl |
| Target Point | EGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling |
| Background | PD153035 Hydrochloride/SU-5271 Hydrochloride is a potent EGFR inhibitor. |
| Biological Activity | PD153035 (ZM 252868;AG 1517;Tyrphostin AG 1517;SU 5271) 是有效地 EGFR 抑制剂， Ki 和 IC50 值分别为6和25 pM。 |
| IC50 | EGFR:25 pM [1-4] |
| Data Literature Source | [1]. Bridges AJ，et al. Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6，7-dimethoxyquinazoline (PD 153035)，a potent inhibitor of the epidermal growth factor receptor. J Med Chem. 1996 Jan 5;39(1):267-76. [2]. Fry DW，et al. A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science. 1994 Aug 19;265(5175):1093-5. [3]. Bos M，et al. PD153035，a tyrosine kinase inhibitor，prevents epidermal growth factor receptoractivation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin Cancer Res. 1997 Nov;3(11):2099-106. [4]. Kunkel MW，et al. Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice. Invest New Drugs. 1996;13(4):295-302. |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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