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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > SB-202190CAS：152121-30-7
Molecular Formula：C20H14FN3O
Molecular Weight：331.34
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to yellow Solid
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| CAS | 152121-30-7 |
| Name | SB-202190 |
| Molecular Formula | C20H14FN3O |
| Molecular Weight | 331.34 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00072248 |
| SMILES | FC1=CC=C(C2=C(C3=CC=NC=C3)NC(C4=CC=C(O)C=C4)=N2)C=C1 |
| InChIKey | QHKYPYXTTXKZST-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24) |
| PubChem CID | 5169 |
| Target Point | p38 MAPK |
| Passage | MAPK |
| Background | SB 202190 is a cell-permeable p38 MAPK inhibitor. |
| Biological Activity | SB 202190 是可渗透细胞的 p38 MAPK 抑制剂，抑制p38 和 p38β2的 IC50 分别为50 nM 和 100 nM。[1-5] |
| IC50 | 50nM(p38)，100nM(p38β2)[1] |
| Data Literature Source | [1]. Davies SP，et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. [2]. Nemoto S，et al. Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase. J Biol Chem. 1998 Jun 26;273(26):16415-20. [3]. Grossi V，et al. Sorafenib inhibits p38α activity in colorectal cancer cells and synergizes with the DFG-in inhibitor SB202190 to increase apoptotic response. Cancer Biol Ther. 2012 Dec;13(14):1471-81. [4]. Yang S，et al. Protective effects of p38 MAPK inhibitor SB202190 against hippocampal apoptosis and spatial learning and memory deficits in a rat model of vascular dementia. Biomed Res Int. 2013;2013:215798. [5]. Zhang Y，et al. PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer. EBioMedicine. 2015 Nov 19;2(12):1944-56 |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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