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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > SU 11274CAS：658084-23-2
Molecular Formula：C28H30CIN5O4S
Molecular Weight：568.09
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 658084-23-2 |
| Name | SU 11274 |
| Molecular Formula | C28H30CIN5O4S |
| Molecular Weight | 568.09 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD08276928 |
| SMILES | O=S(C1=CC2=C(C=C1)NC(/C2=C/C3=C(C(C(N4CCN(CC4)C)=O)=C(N3)C)C)=O)(N(C)C5=CC=CC(Cl)=C5)=O |
| Target Point | c-Met/HGFR |
| Passage | Protein Tyrosine Kinase/RTK |
| Background | SU11274 is a selective Met inhibitor. |
| Biological Activity | SU11274 是一种选择性的 Met 抑制剂, IC50 值为 10 nM, 对 PGDFRβ, EGFR 或 Tie2 没有抑制作用[1]。 |
| IC50 | IC50: 10nM (Met) [1] |
| Data Literature Source | [1]. Wang X， et al. Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion. Mol Cancer Ther， 2003， 2 (11) :1085-1092. [2]. Sattler M， et al. A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. Cancer Res， 2003， 63 (17) ， 5462-5469. [3]. Ma PC， et al. Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer. Cancer Res， 2005， 65 (4) ， 1479-1488. |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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