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Tozasertib

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Cat.No：IT1260 Solarbio

CAS：639089-54-6

Molecular Formula：C₂₃H₂₈N₈OS

Molecular Weight：464.59

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	639089-54-6
Name	Tozasertib
Molecular Formula	C₂₃H₂₈N₈OS
Molecular Weight	464.59
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD13185152
SMILES	CC1=CC(NC2=NC(SC3=CC=C(C=C3)NC(C4CC4)=O)=NC(N5CCN(CC5)C)=C2)=NN1
Target Point	Aurora Kinase
Passage	Cell Cycle
Background	Tozasertib is an Aurora A/B/C kinase inhibitor.
Biological Activity	Tozasertib 是 Aurora A/B/C 激酶抑制剂，Ki 值分别为 0.6，18，4.6 nM。[1-3]
Data Literature Source	[1]. Harrington EA，et al. VX-680，a potent and selective smallmolecule inhibitor of the Aurora kinases，suppresses tumor growth in vivo. Nat Med. 2004; 10:262-7. [2]. Salah E，et al. Crystal structures of ABL-related gene (ABL2) in complex with imatinib，tozasertib (VX-680)，and a type I inhibitor of the triazole carbothioamide class.J Med Chem. 2011 Apr 14;54(7):2359-67. Epub 2011 Mar 18. [3]. Arlot-Bonnemains Y，et al. Effects of the Aurora kinase inhibitor VX-680 on anaplastic thyroid cancer-derived cell lines. Endocr Relat Cancer. 2008 Jun;15(2):559-68
Unit	Bottle
Specification	10mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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