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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > ZSTK474CAS：475110-96-4
Molecular Formula：C19H21F2N7O2
Molecular Weight：417.41
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 475110-96-4 |
| Name | ZSTK474 |
| Molecular Formula | C19H21F2N7O2 |
| Molecular Weight | 417.41 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD08705334 |
| SMILES | FC(C1=NC2=C(N1C3=NC(N4CCOCC4)=NC(N5CCOCC5)=N3)C=CC=C2)F |
| Target Point | PI3K |
| Passage | PI3K/Akt/mTOR |
| Background | ZSTK474 is an ATP-competitive pan-class I PI3K inhibitor. |
| Biological Activity | ZSTK474 是一种 ATP 竞争性的泛 I 类 PI3K 抑制剂，抑制 P13Kα，PI3Kβ，PI3Kδ 和 PI3Kγ，IC50 分别为 16 nM，44 nM，4.6 nM 和 49 nM。[1-3] |
| Data Literature Source | [1]. Kong D，et al. ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms. Cancer Sci，2007，98(10)，1638-1642. [2]. Wang P，et al. Class I PI3K inhibitor ZSTK474 mediates a shift in microglial/macrophage phenotype and inhibits inflammatory response in mice with cerebral ischemia/reperfusion injury. J Neuroinflammation. 2016 Aug 22;13(1):192. [3]. Liu F，et al. Prolonged inhibition of class I PI3K promotes liver cancer stem cell expansion by augmenting SGK3/GSK-3β/β-catenin signalling. J Exp Clin Cancer Res. 2018 Jun 25;37(1):122. |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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