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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > ClofarabineCAS：123318-82-1
Molecular Formula：C10H11ClFN5O3
Molecular Weight：303.68
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 123318-82-1 |
| Name | Clofarabine |
| Molecular Formula | C10H11ClFN5O3 |
| Molecular Weight | 303.68 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 631-422-9 |
| MDL | MFCD00871077 |
| SMILES | F[C@H]([C@H](N1C2=C(C(N)=NC(Cl)=N2)N=C1)O[C@@H]3CO)[C@@H]3O |
| Target Point | DNA/RNA Synthesis |
| Passage | Cell Cycle;DNA Damage/DNA Repair |
| Background | It can inhibit nucleotide reductase and DNA polymerase activity. |
| Biological Activity | Clofarabine (Clolar)抑制 ribonucleotide reductase (RNR) (IC50 = 65 nM)和 DNA polymerase 的酶活性。Clofarabine 可诱导自噬和凋亡。[1-3] |
| IC50 | Ribonucleotide reductase(Cell-free assay):65nM [1] |
| Data Literature Source | [1] Bonate PL，et al. Nat Rev Drug Discov，2006，5(10)，855-863. [2] Yamauchi T，et al. Clin Cancer Res，2001，7(11)，3580-3589. [3] Cooper T，et al. Cancer Chemother Pharmacol，2005，55(4)，3 |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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