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Idarubicin Hydrochloride

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Cat.No：II0730 Solarbio

CAS：57852-57-0

Molecular Formula：C₂₆H₂₇NO₉·HCl

Molecular Weight：533.95

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

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Product Information

CAS	57852-57-0
Name	Idarubicin Hydrochloride
Molecular Formula	C₂₆H₂₇NO₉·HCl
Molecular Weight	533.95
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 260-990-7
MDL	MFCD00897212
SMILES	OC(C(C(C1=CC=CC=C21)=O)=C3C2=O)=C4[C@H](C[C@@](C(C)=O)(O)CC4=C3O)O[C@@](O[C@@H](C)[C@H]5O)([H])C[C@@H]5N.Cl
Target Point	Topoisomerase
Passage	DNA Damage/DNA Repair
Background	ICI 118,551 hydrochloride is a highly selective β2 adrenergic receptor antagonist.
Biological Activity	Idarubicin hydrochloride是一种蒽环类抗白血病试剂。它抑制拓扑异构酶II，干扰DNA复制和RNA转录。[1-4]
Data Literature Source	[1]. Orlandi P， et al. Idarubicin and idarubicinol effects on breast cancer multicellular spheroids. J Chemother. 2005 Dec; 17 (6) :663-7. [2]. Robert J. Clinical pharmacokinetics of idarubicin. Clin Pharmacokinet. 1993 Apr; 24 (4) :275-88. [3]. Siegsmund MJ， et al. Enhanced in vitro cytotoxicity of idarubicin compared to epirubicin and doxorubicin in rat prostate carcinoma cells. Eur Urol. 1997; 31 (3) :365-70. [4]. Gewirtz DA， et al. Induction of DNA damage， inhibition of DNA synthesis and suppression of c-myc expression by the anthracycline analog， idarubicin (4-demethoxy-daunorubicin) in the MCF-7 breast tumor cell line. Cancer Chemother Pharmacol. 1998; 41 (5) :361
Unit	Bottle
Specification	5mg 25mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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