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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > TivozanibCAS：475108-18-0
Molecular Formula：C22H19ClN4O5
Molecular Weight：454.86
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light brown to brown Solid
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| CAS | 475108-18-0 |
| Name | Tivozanib |
| Molecular Formula | C22H19ClN4O5 |
| Molecular Weight | 454.86 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light brown to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00014996 |
| SMILES | O=C(NC1=CC=C(C=C1Cl)OC2=CC=NC3=CC(OC)=C(C=C23)OC)NC4=NOC(C)=C4 |
| Target Point | VEGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK |
| Background | Tivozanib/AV-951/KRN951 is a potent and selective VEGFR 1/2/3 inhibitor. |
| Biological Activity | Tivozanib 是有效，选择性的 VEGFR 1/2/3 抑制剂，IC50 值分别为0.21，0.16，and 0.24 nM。[1] |
| Data Literature Source | [1]. Nakamura K，et al. KRN951，a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases，has antitumor activities and affects functional vascular properties. Cancer Res. 2006 Sep 15;66(18):9134-42 |
| Unit | Bottle |
| Specification | 5mg 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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