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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > AMG 208CAS：1002304-34-8
Molecular Formula：C22H17N5O2
Molecular Weight：383.4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1002304-34-8 |
| Name | AMG 208 |
| Molecular Formula | C22H17N5O2 |
| Molecular Weight | 383.4 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD17215205 |
| SMILES | COC1=CC=C2C(OCC3=NN=C4N3N=C(C=C4)C5=CC=CC=C5)=CC=NC2=C1 |
| Target Point | c-Met/HGFR;RON |
| Passage | Protein Tyrosine Kinase/RTK |
| Background | It is a potent, selective dual inhibitor of c-Met/RON and a CYP3A4 inhibitor. |
| Biological Activity | AMG-208 是一种高度选择性的 c-Met 和 RON 的双重抑制剂，对c-Met的IC50值为9 nM。[1] |
| Data Literature Source | [1] Albrecht BK，et al. J Med Chem. 2008，51(10)，2879-2882. [2] Boezio AA，et al. Bioorg Med Chem Lett. 2009，19(22)，6307-6312. [3] Liu X，et al. Trends Mol Med. 2010，16(1)，37-45. |
| Unit | Bottle |
| Specification | 5mg 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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