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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Asenapine maleateCAS：85650-56-2
Molecular Formula：C17H16ClNO·C4H4O4
Molecular Weight：401.84
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：White to off-white Solid
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| CAS | 85650-56-2 |
| Name | Asenapine maleate |
| Molecular Formula | C17H16ClNO·C4H4O4 |
| Molecular Weight | 401.84 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 288-064-8 |
| MDL | MFCD00002090 |
| SMILES | CN1C[C@]2([H])C3=CC=CC=C3OC4=CC=C(Cl)C=C4[C@]2(C1)[H].O=C(O)/C=C\C(O)=O |
| Target Point | 5-HT Receptor |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | Asenapine maleate is a 5-HT and D2 antagonist. |
| Biological Activity | Asenapine maleate是 5-HT(1A, 1B, 2A, 2B, 2C, 5A, 6, 7) 和 D2 的拮抗剂，Ki 值分别为 0.03-4.0 nM, 1.3 nM。同时也是一种抗精神病药物。[1-4] |
| Data Literature Source | [1]. Stoner SC，et al. Asenapine: a clinical review of a second-generation antipsychotic. Clin Ther. 2012 May;34(5):1023-40. [2]. Shahid M，et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23(1):65-73. [3]. Ohyama M，et al. Asenapine reduces anxiety-related behaviours in rat conditioned fear stress model. Acta Neuropsychiatr. 2016 Dec;28(6):327-336. [4]. Ene HM，et al. Effects of repeated asenapine in a battery of tests for anxiety-like behaviours in mice. Acta Neuropsychiatr. 2016 Apr;28(2):85-91. |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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