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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > BX795CAS：702675-74-9
Molecular Formula：C23H26IN7O2S
Molecular Weight：591.47
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 702675-74-9 |
| Name | BX795 |
| Molecular Formula | C23H26IN7O2S |
| Molecular Weight | 591.47 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-256-5 |
| MDL | MFCD12546134 |
| SMILES | O=C(NCCCNC1=C(C=NC(NC2=CC=CC(NC(N3CCCC3)=O)=C2)=N1)I)C4=CC=CS4 |
| Target Point | PDK-1; IKK; TBK1;Autophagy |
| Passage | PI3K/Akt/mTOR;NF-κB;Immunology & Inflammation;Autophagy |
| Background | BX795 is an effective and selective inhibitor of PDK1, as well as an effective and relatively specific inhibitor of TBK1 and IKK doing so. BX795 inhibits the phosphorylation of S6K1, Akt, PKCδ and GSK3β. BX795 also regulates autophagy. |
| Biological Activity | BX795是有效，选择性的 PDK1 抑制剂，IC50为6 nM， 比PKA，PKC，c-Kit，GSK3β的选择性高50多倍[1-3]。 |
| IC50 | 2nM(TBK1)，6nM(PDK1)[1-3] |
| Data Literature Source | [1]. Feldman RI，et al. Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74. [2]. Clark K，et al. Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation. J Biol Chem. 2009 May 22;284(21):141 [3]. Dangelmaier C，et al. PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses. Thromb Haemost. 2014 Mar 3;111(3):508-17. |
| Unit | Bottle |
| Specification | 5mg 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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