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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > CilostazolCAS：73963-72-1
Molecular Formula：C20H27N5O2
Molecular Weight：369.46
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：White to off-white Solid
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| CAS | 73963-72-1 |
| Name | Cilostazol |
| Molecular Formula | C20H27N5O2 |
| Molecular Weight | 369.46 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 689-122-9 |
| MDL | MFCD00866780 |
| SMILES | O=C1NC2=C(C=C(OCCCCC3=NN=NN3C4CCCCC4)C=C2)CC1 |
| InChIKey | RRGUKTPIGVIEKM-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26) |
| PubChem CID | 2754 |
| Target Point | Phosphodiesterase (PDE) |
| Passage | Metabolic Enzyme&Protease |
| Background | It is a potent and selective inhibitor of phosphodiesterase type 3 (PDE3). It is also an inhibitor of adenosine uptake. |
| Biological Activity | Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC50 of 0.2 μM[1-2]. |
| IC50 | 0.2μM( PDE 3A)[1] |
| Data Literature Source | [1]. Schr r K. The pharmacology of cilostazol. Diabetes Obes Metab. 2002 Mar;4 Suppl 2:S14-9. [2]. Minami N，et al. Inhibition of shear stress-induced platelet aggregation by cilostazol，a specific inhibitor of cGMP-inhibited phosphodiesterase，in vitro and ex vivo. Life Sci. 1997;61(25):PL 383-9. [3]. Saito S，et al. Cilostazol attenuates hepatic stellate cell activation and protects mice against carbon tetrachloride-induced liver fibrosis. Hepatol Res. 2013 Apr 19. |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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