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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > DoxazosinCAS：77883-43-3
Molecular Formula：C24H29N5O8S
Molecular Weight：547.58
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 77883-43-3 |
| Name | Doxazosin |
| Molecular Formula | C24H29N5O8S |
| Molecular Weight | 547.58 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1308068-626-2 |
| MDL | MFCD00216023 |
| SMILES | O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)C4OC5=CC=CC=C5OC4.CS(=O)(O)=O |
| InChIKey | VJECBOKJABCYMF-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H25N5O5.CH4O3S/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20;1-5(2,3)4/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26);1H3,(H,2,3,4) |
| PubChem CID | 62978 |
| Target Point | Adrenergic Receptor |
| Passage | Endocrinology & Hormones;GPCR & G Protein;Neuronal Signaling |
| Background | It selectively antagonizes postsynaptic α1 adrenergic receptors. |
| Biological Activity | Doxazosin mesylate (UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic聽伪1-adrenergic receptors. |
| IC50 | α adrenergic receptor |
| Data Literature Source | [1]. Sun，J.A.，et al.，Stereoselective binding of doxazosin enantiomers to plasma proteins from rats，dogs and humans in vitro. Acta Pharmacol Sin，2013. 34(12): p. 1568-74. [2]. D'Eletto，R.D. and N.B. Javitt，Effect of doxazosin on cholesterol synthesis in cell culture. J Cardiovasc Pharmacol，1989. 13 Suppl 2: p. S1-4; discussion S4. [3]. Miura，Y. and K. Yoshinaga，Doxazosin: a newly developed，selective alpha 1-inhibitor in the management of patients with pheochromocytoma. Am Heart J，1988. 116(6 Pt 2): p. 1785-9. |
| Unit | Bottle |
| Specification | 100mg 500mg 1g |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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