{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > AT 7867CAS：857531-00-1
Molecular Formula：C20H20ClN3
Molecular Weight：337.85
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 857531-00-1 |
| Name | AT 7867 |
| Molecular Formula | C20H20ClN3 |
| Molecular Weight | 337.85 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18384971 |
| SMILES | ClC1=CC=C(C=C1)C2(CCNCC2)C3=CC=C(C=C3)C4=CNN=C4 |
| Target Point | Akt;p70S6K;PKA |
| Passage | PI3K/Akt/mTOR;MAPK;Stem Cells; Protein Tyrosine Kinase/RTK |
| Background | AT7867 is an ATP-competitive inhibitor of Akt1/Akt2/Akt3 and p70S6K/PKA. |
| Biological Activity | AT7867 是一种 ATP 竞争性的 Akt1/Akt2/Akt3 和 p70S6K/PKA 抑制剂，IC50 分别为 32 nM/17 nM/47 nM 和 85 nM/20 nM[1]。 |
| IC50 | Akt2:17nM;Akt1:32nM;Akt3:47nM PKA:20nM [1] |
| Data Literature Source | [1]. Grimshaw KM，et al. AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth. Mol Cancer Ther，2010，9(5)，1100-1110. |
| Unit | Bottle |
| Specification | 2mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
