{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > CP-673451CAS：343787-29-1
Molecular Formula：C24H27N5O2
Molecular Weight：417.5
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 343787-29-1 |
| Name | CP-673451 |
| Molecular Formula | C24H27N5O2 |
| Molecular Weight | 417.5 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD11100329 |
| SMILES | NC1CCN(C2=C3N=C(C=CC3=CC=C2)N4C=NC5=CC(OCCOC)=CC=C54)CC1 |
| Target Point | PDGFR |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | CP-673451 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR). |
| Biological Activity | CP-673451 是一种有效的，选择性的血小板源生长因子受体 (PDGFR) 抑制剂，抑制 PDGFRα 和 PDGFRβ 的活性，IC50 值分别为 10 和 1 nM[1-4]。 |
| IC50 | PDGFRα:10nM;PDGFRβ:1nM [1-4] |
| Data Literature Source | [1]. Xi Y，et al. CP-673451，a platelet-derived growth-factor receptor inhibitor，suppresses lung cancer cell proliferation and migration. Onco Targets Ther. 2014 Jul 3;7:1215-21. [2]. Konotop G，et al. Pharmacological Inhibition of Centrosome Clustering by Slingshot-Mediated Cofilin Activation and Actin Cortex Destabilization. Cancer Res. 2016 Nov 15;76(22):6690-6700. [3]. Ehnman M，et al. Distinct effects of ligand-induced PDGFRα and PDGFRβ signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartments. Cancer Res，2013，73(7)，2139-2149. [4]. Roberts WG，et al. Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor，CP-673，451. Cancer Res，2005，65(3)，957-966. |
| Unit | Bottle |
| Specification | 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
