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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > Fasudil HydrochlorideCAS：105628-07-7
Molecular Formula：C14H17N3O2S·HCl
Molecular Weight：327.83
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 105628-07-7 |
| Name | Fasudil Hydrochloride |
| Molecular Formula | C14H17N3O2S·HCl |
| Molecular Weight | 327.83 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 805-833-0 |
| MDL | MFCD00943198 |
| SMILES | O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCCC3)=O.Cl[H] |
| Target Point | ROCK;PKC;PKA;PKG |
| Passage | Cytoskeleton; Cell Cycle;TGF-beta/Smad;Stem Cells;Protein Tyrosine Kinase/RTK |
| Background | Fasudil is a potent ROCK1, PKA, PKC and mLCK inhibitor. |
| Biological Activity | Fasudil 是一种有效的 ROCK1，PKA，PKC 和 MLCK 抑制剂，Ki 值分别为 0.33 μM，1.0 μM，9.3 μM 和 55 μM。[1-8] |
| Data Literature Source | [1]. Ono-Saito N，et al. H-series protein kinase inhibitors and potential clinical applications. Pharmacol Ther. 1999 May-Jun;82(2-3):123-31. [2]. Asano T，et al. Mechanism of action of a novel antivasospasm drug，HA1077. J Pharmacol Exp Ther. 1987 Jun;241(3):1033-40. [3]. Asano T，et al. Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase. Br J Pharmacol. 1989 Dec;98(4):1091-100. [4]. Negoro N，et al. The kinase inhibitor fasudil (HA-1077) reduces intimal hyperplasia through inhibiting migration and enhancing cell loss of vascular smooth muscle cells. Biochem Biophys Res Commun. 1999 Aug 19;262(1):211-5. [5]. Fukushima M，et al. Fasudil hydrochloride hydrate，a Rho-kinase (ROCK) inhibitor，suppresses collagen production and enhances collagenase activity in hepatic stellate cells. Liver Int. 2005 Aug;25(4):829-38. [6]. Zhang J，et al. Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation. Clin Chim Acta. 2009 Mar;401(1-2):76-80. [7]. Sun X，et al. The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2006 Nov;180(1-2):126-34 [8]. Uehata M，et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 1997 Oct 30;389(6654):990-4. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 10mM*1mL in Water 200mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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