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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > KRN 633CAS：286370-15-8
Molecular Formula：C20H21ClN4O4
Molecular Weight：416.86
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：White to off-white Solid
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| CAS | 286370-15-8 |
| Name | KRN 633 |
| Molecular Formula | C20H21ClN4O4 |
| Molecular Weight | 416.86 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD14155620 |
| SMILES | ClC1=CC(OC2=NC=NC3=CC(OC)=C(C=C32)OC)=CC=C1NC(NCCC)=O |
| Target Point | VEGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK |
| Background | KRN-633 is a potent inhibitor of VEGFR. |
| Biological Activity | KRN-633 是 VEGFR 的有效抑制剂，对VEGFR1，VEGFR2 和 VEGFR3的IC50 值分别为170，160和125 nM[1]。 |
| IC50 | VEGFR1:170nM;VEGFR2:160nM;VEGFR3:125nM [1] |
| Data Literature Source | [1]. Nakamura K，et al. KRN633: A selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase that suppresses tumor angiogenesis and growth. Mol Cancer Ther. 2004 Dec;3(12):1639-49 |
| Unit | Bottle |
| Specification | 5mg 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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