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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > Org 27569CAS：868273-06-7
Molecular Formula：C24H28ClN3O
Molecular Weight：409.95
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 868273-06-7 |
| Name | Org 27569 |
| Molecular Formula | C24H28ClN3O |
| Molecular Weight | 409.95 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 278-169-7 |
| MDL | MFCD11045300 |
| SMILES | ClC1=CC=C(C2=C1)NC(C(NCCC3=CC=C(C=C3)N4CCCCC4)=O)=C2CC |
| Target Point | Cannabinoid Receptor |
| Passage | GPCR & G Protein;Neuronal Signaling |
| Background | Org 27569 is a potent CB1 receptor allosteric modulator, which can both increase agonist binding to CB1 and inhibit agonist-induced CB1 signaling. |
| Biological Activity | Org 27569 是有效的 CB1 receptor 别构调节剂，既能增加激动剂与 CB1 结合，又能抑制激动剂诱导的 CB1 信号通路[1-5]。 |
| Data Literature Source | [1]. Jing L，et al. Effects of the cannabinoid CB receptor allosteric modulator ORG 27569 on reinstatement of cocaine- and methamphetamine-seeking behavior in rats. Drug Alcohol Depend. 2014 Oct 1;143:251-6. [2]. Fay JF，et al. A key agonist-induced conformational change in the cannabinoid receptor CB1 is blocked by the allosteric ligand Org 27569. J Biol Chem. 2012 Jul 30. [3]. Gamage TF，et al. In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569. Behav Pharmacol. 2014 Apr;25(2):182-5. [4]. Price MR，et al. Allosteric modulation of the cannabinoid CB1 receptor. Mol Pharmacol. 2005 Nov;68(5):1484-95. [5]. Baillie GL，et al. CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity. Mol Pharmacol. 2013 Feb;83(2):322-38. |
| Unit | Bottle |
| Specification | 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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