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TWS 119

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Cat.No：IT1520 Solarbio

CAS：601514-19-6

Molecular Formula：C₁₈H₁₄N₄O₂

Molecular Weight：318.33

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to brown Solid

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Product Information

CAS	601514-19-6
Name	TWS 119
Molecular Formula	C₁₈H₁₄N₄O₂
Molecular Weight	318.33
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to brown Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD09037535
SMILES	OC1=CC=CC(OC2=C3C(NC(C4=CC=CC(N)=C4)=C3)=NC=N2)=C1
Target Point	GSK-3
Passage	PI3K/Akt/mTOR;Stem Cells
Background	TWS119 is a GSK-3β-specific inhibitor.
Biological Activity	TWS119 是一种 GSK-3β 特异性抑制剂，IC50 值为 30 nM，同时可激活 wnt/β-catenin 信号通路。[1-3]
IC50	GSK-3β:30nM [1-3]
Data Literature Source	[1]. Ding S，et al. Synthetic small molecules that control stem cell fate. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7632-7. Epub 2003 Jun 6. [2]. Wang W，et al. GSK-3β inhibitor TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats. Mol Neurobiol. 2016 Dec;53(10):7028-7036. Epub 2015 Dec 15. [3]. Chen YQ，et al. Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human γδT cells against colon cancer. Exp Cell Res. 2017 Nov 16. pii: S0014-4827(17)30587-6
Unit	Bottle
Specification	10mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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