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Vadimezan

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Cat.No：IV0460 Solarbio

CAS：117570-53-3

Molecular Formula：C₁₇H₁₄O₄

Molecular Weight：282.29

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	117570-53-3
Name	Vadimezan
Molecular Formula	C₁₇H₁₄O₄
Molecular Weight	282.29
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 700-141-4
MDL	MFCD00870555
SMILES	O=C(O)CC1=CC=CC(C2=O)=C1OC3=C2C=CC(C)=C3C
Target Point	STING
Passage	Immunology & Inflammation
Background	Vadimezan is a vascular disrupting agent, a stimulator of STING, and a potent inducer of type I IFN and other cytokines.
Biological Activity	Vadimezan (ASA-404; DMXAA) 是血管破坏剂，是鼠干扰素基因 (STING) 刺激物，也是I型IFN和其他细胞因子的强效诱导剂。[1-2]
Data Literature Source	[1]. Downey CM，et al. DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer，and like the endogenous non-canonical cyclic dinucleotide STING agonist，2'3'-cGAMP，induces M2 macrophage repolarization. PLoS One. 2014 Jun 18;9(6):e99988. [2]. Shirey KA，et al. The anti-tumor agent，5，6-dimethylxanthenone-4-acetic acid (DMXAA)，induces IFN-beta-mediated antiviral activity in vitro and in vivo. J Leukoc Biol. 2011 Mar;89(3):351-7.
Unit	Bottle
Specification	10mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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