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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > FlumazenilCAS：78755-81-4
Molecular Formula：C15H14FN3O3
Molecular Weight：303.29
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：White to off-white Solid
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| CAS | 78755-81-4 |
| Name | Flumazenil |
| Molecular Formula | C15H14FN3O3 |
| Molecular Weight | 303.29 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 616-650-9 |
| MDL | MFCD00242764 |
| SMILES | O=C(C1=C2CN(C(C3=CC(F)=CC=C3N2C=N1)=O)C)OCC |
| InChIKey | OFBIFZUFASYYRE-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3 |
| PubChem CID | 3373 |
| Target Point | GABA Receptor |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | Flumazenil is a competitive GABAA receptor antagonist. |
| Biological Activity | Flumazenil 是一种有竞争性的 GABAA receptor 拮抗剂，用于治疗苯二氮类药物过量问题。[1-5] |
| Data Literature Source | [1]. Hoffman EJ，et al. Flumazenil: a benzodiazepine antagonist. Clin Pharm. 1993 Sep;12(9):641-56; quiz 699-701. [2]. Belzung C，et al. Flumazenil induces benzodiazepine partial agonist-like effects in BALB/c but not C57BL/6 mice. Psychopharmacology (Berl). 2000 Jan;148(1):24-32. [3]. Fernandez-Guasti A，et al. Flumazenil blocks the anxiolytic action of allopregnanolone. Eur J Pharmacol. 1995 Jul 25;281(1):113-5. [4]. Loscher W，et al. Effects of the non-NMDA antagonists NBQX and the 2，3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil. Br J Pharmacol. 1994 Dec;113(4):1349-57. [5]. Moy SS，et al. Flumazenil blockade of anxiety following ethanol withdrawal in rats. Psychopharmacology (Berl). 1997 Jun;131(4):354-60 |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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