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IC-87114

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Cat.No：II0740 Solarbio

CAS：371242-69-2

Molecular Formula：C₂₂H₁₉N₇O

Molecular Weight：397.43

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	371242-69-2
Name	IC-87114
Molecular Formula	C₂₂H₁₉N₇O
Molecular Weight	397.43
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
SMILES	O=C1N(C(CN2C3=C(C(N)=NC=N3)N=C2)=NC4=CC=CC(C)=C14)C5=C(C)C=CC=C5
Target Point	PI3K
Passage	PI3K/Akt/mTOR
Background	IC261 is a selective ATP-competitive inhibitor of CK1.
Biological Activity	IC-87114 是一种有效的选择性 PI3Kδ 抑制剂，IC50 为 0.5 μM。[1-3]
IC50	PI3Kδ:0.5μM;PI3Kγ:29μM;PI3Kβ:75μM;[1-3]
Data Literature Source	[1]. Sadhu C，et al. Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. J Immunol. 2003 Mar 1;170(5):2647-54. [2]. Zheng L，et al. Inactivation of PI3Kδ induces vascular injury and promotes aneurysm development by upregulating the AP-1/MMP-12 pathway in macrophages. Arterioscler Thromb Vasc Biol. 2015 Feb;35(2):368-77. [3]. El-Hashim AZ，et al. Src-dependent EGFR transactivation regulates lung inflammation via downstream signaling involving ERK1/2，PI3Kδ/Akt and NFκB induction in a murine asthma model. Sci Rep. 2017 Aug 30;7(1):9919.
Unit	Bottle
Specification	5mg 10mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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