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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > KI 8751CAS：228559-41-9
Molecular Formula：C24H18F3N3O4
Molecular Weight：469.41
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 228559-41-9 |
| Name | KI 8751 |
| Molecular Formula | C24H18F3N3O4 |
| Molecular Weight | 469.41 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD09971092 |
| SMILES | COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C(F)=C3)NC(NC4=CC=C(C=C4F)F)=O |
| Target Point | VEGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK |
| Background | Ki8751 is a potent VEGFR2 inhibitor. |
| Biological Activity | Ki8751是有效地 VEGFR2 抑制剂，IC50 值为0.9 nM，并且还分别以67nM和40nM抑制PDGFR家族成员如PDGFRR和c-Kit。Ki8751对其他激酶如EGFR，HGFR，胰岛素R等甚至在10000nM时也没有任何抑制活性[1]。 |
| IC50 | VEGFR2:0.9nM [1] |
| Data Literature Source | [1]. Kubo K，et al. Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis，structure-activity relationships，and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas. J Med Chem，2005，48(5)，1359-1366 |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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