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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > RamelteonCAS：196597-26-9
Molecular Formula：C16H21NO2
Molecular Weight：259.35
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 196597-26-9 |
| Name | Ramelteon |
| Molecular Formula | C16H21NO2 |
| Molecular Weight | 259.35 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-835-2 |
| MDL | MFCD08067736 |
| SMILES | O=C(NCC[C@H]1C2=C(C=CC3=C2CCO3)CC1)CC |
| Target Point | Melatonin Receptor(MT Receptor) |
| Passage | GPCR & G Protein;Neuronal Signaling |
| Background | Ramelteon is a potent and selective melatonin receptor agonist. |
| Biological Activity | Ramelteon是高效选择性的melatonin受体激动剂，结合人melatonin1和melatonin2受体的Ki值分别为14 和112 pM。[1-4] |
| IC50 | 14 pM(melatonin1)，112 pM(melatonin2)[1] |
| Data Literature Source | [1]. Kato K，et al. Neurochemical properties of ramelteon (TAK-375)，a selective MT1/MT2 receptor agonist. Neuropharmacology. 2005 Feb;48(2):301-10. [2]. Miyamoto M，et al. The sleep-promoting action of ramelteon (TAK-375) in freely moving cats. Sleep. 2004 Nov 1;27(7):1319-25. [3]. Kuriyama A，et al. Ramelteon for the treatment of insomnia in adults: a systematic review and meta-analysis. Sleep Med. 2014 Apr;15(4):385-92. [4]. Fisher SP，et al. Acute sleep-promoting action of the melatonin agonist，ramelteon，in the rat. J Pineal Res. 2008 Sep;45(2):125-32. |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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