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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > Alfuzosin HydrochlorideCAS：81403-68-1
Molecular Formula：C19H27N5O4·HCl
Molecular Weight：425.91
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 81403-68-1 |
| Name | Alfuzosin Hydrochloride |
| Molecular Formula | C19H27N5O4·HCl |
| Molecular Weight | 425.91 |
| Solubility | Soluble in Water/DMSO ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 620-512-3 |
| MDL | MFCD00879135 |
| SMILES | O=C(C1OCCC1)NCCCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)C.Cl |
| Target Point | Adrenergic Receptor |
| Passage | Endocrinology & Hormones;GPCR & G Protein;Neuronal Signaling |
| Background | Alfuzosin hydrochloride/SL 77499-10 is an alpha 1 adrenergic receptor antagonist |
| Biological Activity | Alfuzosin, a new quinazoline derivative, acts as a selective and competitive antagonist of alpha 1-adrenoceptor-mediated contraction of prostatic, prostatic capsule, bladder base and proximal urethral smooth muscle, thereby reducing the tone of these structures. [1]Alfuzosin is a potent selective alpha1-adrenoceptor antagonist in tissues of the lower urinary tract including the human prostate. This provides a pharmacological basis for its use in the treatment of benign prostatic hypertrophy.[2] |
| Data Literature Source | [1]. Wilde MI，et al. Alfuzosin. A review of its pharmacodynamic and pharmacokinetic properties，and therapeutic potential in benign prostatic hyperplasia. Drugs. 1993 Mar;45(3):410-29. [2]. Lefèvre-Borg F，O'Connor SE，Schoemaker H，Hicks PE，Lechaire J，Gautier E，Pierre F，Pimoule C，Manoury P，Langer SZ. Alfuzosin，a selective alpha 1-adrenoceptor antagonist in the lower urinary tract. Br J Pharmacol. 1993 Aug;109(4):1282-9. |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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