Your Position: Home > Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > Aurora A Inhibitor I

Aurora A Inhibitor I

Manual Download

Cat.No：IA1940 Solarbio

CAS：1158838-45-9

Molecular Formula：C₃₁H₃₁ClFN₇O₂

Molecular Weight：588.08

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

Qty：

Size：

Add to cart

Product Information Experimental Images Related Products Related Paper Technical Q&A

Product Information

CAS	1158838-45-9
Name	Aurora A Inhibitor I
Molecular Formula	C₃₁H₃₁ClFN₇O₂
Molecular Weight	588.08
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD16495816
SMILES	O=C(C1=CC=C(C=C1)NC2=C(F)C=NC(NC3=CC=C(C=C3)CC(N4CCN(CC4)CC)=O)=N2)NC5=CC=CC=C5Cl
Target Point	Aurora Kinase
Passage	Cell Cycle
Background	Aurora A inhibitor I is a potent, highly selective Aurora A inhibitor.
Biological Activity	Aurora A inhibitor I是有效，高度选择的 Aurora A 抑制剂，IC50值为3.4 nM[1]。
IC50	Aurora A:3.4nM;Aurora B:3.4μM [1]
Data Literature Source	[1]. Aliagas-Martin I，Burdick D，Corson L，Dotson J，Drummond J，Fields C，Huang OW，Hunsaker T，Kleinheinz T，Krueger E，Liang J，Moffat J，Phillips G，Pulk R，Rawson TE，Ultsch M，Walker L，Wiesmann C，Zhang B，Zhu BY，Cochran AG.A class of 2，4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.J Med Chem. 2009 May 28;52(10):3300-7.
Unit	Bottle
Specification	10mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

Note：

1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.