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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > IspinesibCAS：336113-53-2
Molecular Formula：C30H33ClN4O2
Molecular Weight：517.06
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：White to light yellow Solid
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| CAS | 336113-53-2 |
| Name | Ispinesib |
| Molecular Formula | C30H33ClN4O2 |
| Molecular Weight | 517.06 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | White to light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22628831 |
| SMILES | O=C1N(CC2=CC=CC=C2)C([C@@H](C(C)C)N(CCCN)C(C3=CC=C(C)C=C3)=O)=NC4=CC(Cl)=CC=C14 |
| Target Point | Kinesin |
| Passage | Cytoskeleton |
| Background | Ispinesib is a specific KSP inhibitor. |
| Biological Activity | Ispinesib 是一种特异性的 KSP 抑制剂，Ki app 值为 1.7 nM。[1-3] |
| Data Literature Source | [1]. Lad L，et al. Mechanism of inhibition of human KSP by ispinesib. Biochemistry. 2008 Mar 18;47(11):3576-85. [2]. Purcell JW，et al. Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. Clin Cancer Res. 2010 Jan 15;16(2):566-76. [3]. Davis DA，et al. Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line. BMC Cancer. 2006 Jan 24;6:22 |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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