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Neflamapimod

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Cat.No：IN0860 Solarbio

CAS：209410-46-8

Molecular Formula：C₁₉H₉Cl₂F₂N₃OS

Molecular Weight：436.26

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	209410-46-8
Name	Neflamapimod
Molecular Formula	C₁₉H₉Cl₂F₂N₃OS
Molecular Weight	436.26
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD09834070
SMILES	O=C1N=CN(C(C=C2)=C1C3=C(Cl)C=CC=C3Cl)N=C2SC4=CC=C(F)C=C4F
Target Point	p38 MAPK
Passage	MAPK
Background	Neflamapimod is a potent and selective p38α inhibitor with anti-inflammatory activity.
Biological Activity	Neflamapimod (VX-745) 是有效的，有选择性的 p38α 抑制剂，具有抗炎活性[1-4]。
Data Literature Source	[1]. Duffy JP，et al. The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor. ACS Med Chem Lett. 2011 Jul 28;2(10):758-63. [2]. Pradal J，et al. Intra-articular bioactivity of a p38 MAPK inhibitor and development of an extended-release system. Eur J Pharm Biopharm. 2015 Jun;93:110-7. [3]. Bagley MC，et al. Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells. Bioorg Med Chem Lett. 2007 Sep 15;17(18):5107-10. Epub 2007 Jul 13. [4]. Hideshima T，et al. Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu. Blood，2003，101(2)，703-705.
Unit	Bottle
Specification	10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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