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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > OrantinibCAS：252916-29-3
Molecular Formula：C18H18N2O3
Molecular Weight：310.35
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to yellow Solid
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| CAS | 252916-29-3 |
| Name | Orantinib |
| Molecular Formula | C18H18N2O3 |
| Molecular Weight | 310.35 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD01861079 |
| SMILES | CC1=C(/C=C2C3=CC=CC=C3NC/2=O)NC(C)=C1CCC(O)=O |
| Target Point | PDGFR;PDGFR;Flk-1;FGFR1 |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | Orantinib is a multi-targeted receptor tyrosine kinase inhibitor. |
| Biological Activity | Orantinib是多靶点的受体酪氨酸激酶抑制剂，对Flt-1，PDGFRβ 和FGFR1 的 Ki 值分别为 2.1 μM，8 nM 和 1.2 μM[1-4]。 |
| Data Literature Source | [1]. Laird AD，et al. SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. Cancer Res，2000，60(15)，4152-4160. [2]. Smolich BD，et al. The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts. Blood，2001，97(5)，1413-1421. [3]. Marzola P，et al. In vivo assessment of antiangiogenic activity of SU6668 in an experimental colon carcinoma model. Clin Cancer Res，2004，10(2)，739-750. [4]. Kim HC，et al. Augmentation of chemotherapeutic infusion effect by TSU-68，an oral targeted antiangiogenic agent，in a rabbit VX2 liver tumor model. Cardiovasc Intervent Radiol. 2012 Feb;35(1):168-75 |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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