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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > PHA-680632CAS：398493-79-3
Molecular Formula：C28H35N7O2
Molecular Weight：501.62
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥95%
Appearance：White to off-white Solid
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| CAS | 398493-79-3 |
| Name | PHA-680632 |
| Molecular Formula | C28H35N7O2 |
| Molecular Weight | 501.62 |
| Solubility | Soluble in DMSO |
| Purity | ≥95% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD16038900 |
| SMILES | O=C(N1CC2=C(NN=C2NC(C3=CC=C(N4CCN(C)CC4)C=C3)=O)C1)NC5=C(C=CC=C5CC)CC |
| Target Point | Aurora Kinase |
| Passage | Cell Cycle |
| Background | PHA-680632 is an Aurora inhibitor. |
| Biological Activity | PHA-680632是极光激酶抑制剂 (aurora) , 对aurora A, B和C的 IC50 值分别为27, 135和120 nM[1-2]。 |
| IC50 | Aurora A:27nM (IC50) Aurora B:135nM (IC50) Aurora C:120nM (IC50) [1-2] |
| Data Literature Source | [1]. Soncini C， et al. PHA-680632， a novel Aurora kinase inhibitor with potent antitumoral activity. Clin Cancer Res. 2006 Jul 1; 12 (13) :4080-9. [2]. Tao Y， et al. Enhancement of radiation response by inhibition of Aurora-A kinase using siRNA or a selective Aurora kinase inhibitor PHA680632 in p53-deficient cancer cells. Br J Cancer. 2007 Dec 17; 97 (12) :1664-72. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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