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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Safinamide mesylateCAS：202825-46-5
Molecular Formula：C17H19FN2O2·CH4O3S
Molecular Weight：398.45
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 202825-46-5 |
| Name | Safinamide mesylate |
| Molecular Formula | C17H19FN2O2·CH4O3S |
| Molecular Weight | 398.45 |
| Solubility | Soluble in Water |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD15145475 |
| SMILES | C[C@H](NCC1=CC=C(OCC2=CC=CC(F)=C2)C=C1)C(N)=O.CS(=O)(O)=O |
| Target Point | MAO-B |
| Passage | Neuronal Signaling |
| Background | Safinamide mesylate is a potent, selective, and reversible inhibitor of monoamine oxidase B (MAO-B) |
| Biological Activity | Safinamide mesylate 是一种有效的、选择性的、可逆的单胺氧化酶 B (MAO-B) 的抑制剂 (IC50=0.098 μM)，对 MAO-A (IC50=580 μM) 选择性较低。Safinamide mesylate 也阻断钠通道和调节谷氨酸 (Glu) 释放，在去极化时 (IC50= 8 μM) 比静息电位 (IC50=262 μM) 时，显示出更大的亲和力。Safinamide mesylate 具有神经保护作用，可用于帕金森病、缺血脑卒中等疾病的研究。[1-3] |
| IC50 | MAO-B:98nM;mAO-A:580nM [1-3] |
| Data Literature Source | [1]. Leonetti F，et al. Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase. J Med Chem，2007，50(20)，4909-4916. [2]. C Caccia，et al.Safinamide: from molecular targets to a new anti-Parkinson drug. Neurology. 2006 Oct 10;67(7 Suppl 2):S18-23. [3]. Michele Morari，et al. Safinamide Differentially Modulates In Vivo Glutamate and GABA Release in the Rat Hippocampus and Basal Ganglia.J Pharmacol Exp Ther. 2018 Feb;364(2):198-206. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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