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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > AEE 788CAS：497839-62-0
Molecular Formula：C27H32N6
Molecular Weight：440.58
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：White to off-white Solid
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| CAS | 497839-62-0 |
| Name | AEE 788 |
| Molecular Formula | C27H32N6 |
| Molecular Weight | 440.58 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD11100351 |
| SMILES | C[C@H](C1=CC=CC=C1)NC2=C(C=C3C(C=C4)=CC=C4CN5CCN(CC)CC5)C(N3)=NC=N2 |
| Target Point | EGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling |
| Background | AEE788 is an inhibitor of EGFR and ErbB2. |
| Biological Activity | AEE788是EGFR和ErbB2的抑制剂, IC50值分别为2和6 nM[1-2]。 |
| IC50 | EGFR:2nM (IC50) ErbB2:6nM (IC50) [1-2] |
| Data Literature Source | [1]. Traxler P， et al. AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res. 2004 Jul 15; 64 (14) :4931-4941. [2]. Park et al. AEE788， a dual tyrosine kinase receptor inhibitor， induces endothelial cell apoptosis in human cutaneous squamous cell carcinoma xenografts in nude mice. Clin Cancer Res. 2005 Mar 1; 11 (5) :1963-1973 |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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