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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > AT 7519CAS：844442-38-2
Molecular Formula：C16H17Cl2N5O2
Molecular Weight：382.24
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 844442-38-2 |
| Name | AT 7519 |
| Molecular Formula | C16H17Cl2N5O2 |
| Molecular Weight | 382.24 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD13184820 |
| SMILES | O=C(NC1=CNN=C1C(NC2CCNCC2)=O)C3=C(Cl)C=CC=C3Cl |
| Target Point | CDK |
| Passage | Cell Cycle |
| Background | AT7519 is a potent CDK inhibitor |
| Biological Activity | AT7519 是一种有效的 CDK 抑制剂，对 CDK1，CDK2，CDK4-CDK6 以及 CDK9 的 IC50 值分别为 210，47，100，13，170 和 <10 nM[1-3]。 |
| Data Literature Source | [1]. Santo L，et al. AT7519，A novel small molecule multi-cyclin-dependent kinase inhibitor，induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition. Oncogene. 2010 Apr 22;29(16):2325-36. [2]. Squires MS，et al. Biological characterization of AT7519，a small-molecule inhibitor of cyclin-dependent kinases，in human tumor cell lines. Biological characterization of AT7519，a small-molecule inhibitor of cyclin-dependent kinases，in human tumor cell lines. [3]. Squires MS，et al. AT7519，a cyclin-dependent kinase inhibitor，exerts its effects by transcriptional inhibition in leukemia cell lines and patient samples. Mol Cancer Ther. 2010 Apr;9(4):920-8. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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