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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > BIX 02188CAS：1094614-84-2
Molecular Formula：C25H24N4O2
Molecular Weight：412.48
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：Solid
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| CAS | 1094614-84-2 |
| Name | BIX 02188 |
| Molecular Formula | C25H24N4O2 |
| Molecular Weight | 412.48 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD14584538 |
| SMILES | O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=CC(CN(C)C)=C3)/C4=CC=CC=C4)N |
| Target Point | MEK inhibitor |
| Passage | MAPK |
| Background | BIX 02188 is a selective MEK5 inhibitor. |
| Biological Activity | BIX 02188是一种选择性的MEK5抑制剂，IC50为4.3 nM，也抑制ERK5催化活性，IC50为810 nM，且不抑制与其密切相关的激酶MEK1， MEK2， ERK2，和JNK2。[1-2] |
| IC50 | MEK5: 4.3nM [1] |
| Data Literature Source | [1] Tatake RJ，et al. Biochem Biophys Res Commun，2008，377(1)，120-125. [2] Li L，et al. Biochem Biophys Res Commun，2008，370(1)，159 |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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