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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > BIX 02189CAS：1094614-85-3
Molecular Formula：C27H28N4O2
Molecular Weight：440.54
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：Solid
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| CAS | 1094614-85-3 |
| Name | BIX 02189 |
| Molecular Formula | C27H28N4O2 |
| Molecular Weight | 440.54 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18074528 |
| SMILES | O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=CC(CN(C)C)=C3)/C4=CC=CC=C4)N(C)C |
| Target Point | MEK inhibitor |
| Passage | MAPK |
| Background | BIX02189 is a selective MEK5 inhibitor. |
| Biological Activity | BIX02189是一种选择性的MEK5抑制剂，无细胞试验中IC50为1.5 nM，也抑制ERK5催化活性，IC50为59 nM，且不抑制密切相关的激酶MEK1，MEK2，ERK2，和JNK2。[1] |
| IC50 | MEK5: 1.5nM [1] |
| Data Literature Source | [1] Tatake RJ，et al. Biochem Biophys Res Commun，2008，377(1)，120-125. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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