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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > AM1241CAS：444912-48-5
Molecular Formula：C22H22IN3O3
Molecular Weight：503.33
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥99%
Appearance：Solid
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Size：
| CAS | 444912-48-5 |
| Name | AM1241 |
| Molecular Formula | C22H22IN3O3 |
| Molecular Weight | 503.33 |
| Solubility | Soluble in DMSO |
| Purity | ≥99% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CN1CCCCC1CN2C=C(C3=CC=CC=C32)C(=O)C4=C(C=CC(=C4)[N+](=O)[O-])I |
| Target Point | Cannabinoid Receptor agonist |
| Passage | GPCR & G Protein;Neuronal Signaling |
| Background | AM1241 is a potent, typical, and selective CB2 receptor agonist. |
| Biological Activity | AM1241 是一种有效的，典型的[2]，选择性的 CB2 receptor 激动剂，对小鼠脾脏的 CB2 受体的 Ki 值为 3.4 nM，对大鼠大脑 CB1 受体的 Ki 值为 280 nM，在啮齿动物组织中，对 CB2 受体的选择性是对 CB1 受体的 280 倍[1]。 AM1241 能够缓解偏头痛、中风和神经性头痛，对帕金森病也有效果[2]。AM1241 可以抑制氧化损伤，通过 Akt 和 Erk1/2 的磷酸化激活 STAT3[3]。 |
| Data Literature Source | [1]. Ibrahim MM，et al. Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10529-33. [2]. Shi J，et al. AM1241 alleviates MPTP-induced Parkinson's disease and promotes the regeneration of DA neurons in PD mice. Oncotarget. 2017 Jun 29;8(40):67837-67850. [3]. Han D，et al. Activation of cannabinoid receptor type II by AM1241 protects adipose-derived mesenchymal stem cells from oxidative damage and enhances their therapeutic efficacy in myocardial infarction mice via Stat3 activation. Oncotarget. 2017 May 4;8(39):64853-64866. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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