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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > MK-2206 dihydrochlorideCAS：1032350-13-2
Molecular Formula：C25H21N5O·2HCl
Molecular Weight：480.39
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1032350-13-2 |
| Name | MK-2206 dihydrochloride |
| Molecular Formula | C25H21N5O·2HCl |
| Molecular Weight | 480.39 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD14584463 |
| SMILES | O=C1N2C(C3=CC(C4=CC=CC=C4)=C(N=C3C=C2)C5=CC=C(C6(N)CCC6)C=C5)=NN1.Cl.Cl |
| Target Point | Akt |
| Passage | PI3K/Akt/mTOR |
| Background | MK 2206 is an Akt allosteric inhibitor. |
| Biological Activity | MK 2206 是一种口服有效的 Akt 变构抑制剂，抑制 Akt1/Akt2/Akt3 的 IC50 分别为 5 nM/12 nM/65 nM[1-4]。 |
| IC50 | Akt1:5nM;Akt2:12nM;Akt3:65nM [1-4] |
| Data Literature Source | [1]. Zhao YY，et al. Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo. Drug Des Devel Ther. 2014 Oct 10;8:1827-37. [2]. Hirai H，et al. MK-2206，an allosteric Akt inhibitor，enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo. Mol Cancer Therapy，2010，9(7)，1956-1967. [3]. Jain A，et al. Abl kinase regulation by BRAF/ERK and cooperation with Akt in melanoma. Oncogene. 2017 Aug 10;36(32):4585-4596. [4]. Dhar D，et al. Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell. 2018 Jun 11;33(6):1061-1077.e6. |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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