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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > AfloqualoneCAS：56287-74-2
Molecular Formula：C16H14FN3O
Molecular Weight：283.3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to yellow Solid
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| CAS | 56287-74-2 |
| Name | Afloqualone |
| Molecular Formula | C16H14FN3O |
| Molecular Weight | 283.3 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1592732-453-0 |
| MDL | MFCD00867693 |
| SMILES | O=C1N(C2=CC=CC=C2C)C(CF)=NC3=C1C=C(N)C=C3 |
| InChIKey | VDOSWXIDETXFET-UHFFFAOYSA-N |
| InChI | InChI=1S/C16H14FN3O/c1-10-4-2-3-5-14(10)20-15(9-17)19-13-7-6-11(18)8-12(13)16(20)21/h2-8H,9,18H2,1H3 |
| PubChem CID | 2040 |
| Target Point | GABA Receptor |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | Afloqualone is a GABA-A receptor beta subtype agonist. |
| Biological Activity | Afloqualone (HQ-495) is a GABAergic agent and has agonist activity at the β subtype of the GABAα receptor. Afloqualone has antivertiginous and sedative effects thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site[1]. |
| Data Literature Source | [1]. T Ochiai，et al. Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (afloqualone)，a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity. Jpn J Pharmacol. 1982 Jun;32(3):427-38. |
| Unit | Bottle |
| Specification | 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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