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Amoxapine

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Cat.No：IA2170 Solarbio

CAS：14028-44-5

Molecular Formula：C₁₇H₁₆ClN₃O

Molecular Weight：313.78

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to yellow Solid

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Product Information

CAS	14028-44-5
Name	Amoxapine
Molecular Formula	C₁₇H₁₆ClN₃O
Molecular Weight	313.78
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	White to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 237-867-1
MDL	MFCD00069210
SMILES	ClC1=CC=C(OC2=CC=CC=C2N=C3N4CCNCC4)C3=C1
InChIKey	QWGDMFLQWFTERH-UHFFFAOYSA-N
InChI	InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2
PubChem CID	2170
Target Point	GlyT2a;GlyT1b
Passage	Membrane Transporter&Ion Channel
Background	It has strong antidepressant activity and invigorating activity, is the main component of antidepressant, and can be used for related research.
Biological Activity	Amoxapine (CL 67772)是一种三环类Dibenzoxazepine（N-aryl piperazine），与一些其他的三环类抗抑郁药作用相似，Amoxapine抑制GLYT2a的的运输活性，IC50为92 μM。[1]
Data Literature Source	[1] Nez E，et al. Br J Pharmacol，2000，129(1)，200-206. [2] Obers S，et al. Naunyn Schmiedebergs Arch Pharmacol，2010，381(5)，385-400. [3] Hamon M，et al. Neuropharmacology，1987，26(6)，531-539. [4] Maudhuit C，et al. Neuropharmacology，1994，33(8)，1017-1025. [5] Greenblatt EN，et al. Arch Int Pharmacodyn Ther，1978，233(1)，107-135.
Unit	Bottle
Specification	100mg 200mg 500mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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