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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > Apatinib MesylateCAS：1218779-75-9
Molecular Formula：C24H23N5O·CH4O3S
Molecular Weight：493.58
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 1218779-75-9 |
| Name | Apatinib Mesylate |
| Molecular Formula | C24H23N5O·CH4O3S |
| Molecular Weight | 493.58 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1592732-453-0 |
| MDL | MFCD00011914 |
| SMILES | O=C(C1=CC=CN=C1NCC2=CC=NC=C2)NC3=CC=C(C4(C#N)CCCC4)C=C3.CS(=O)(O)=O |
| InChIKey | FYJROXRIVQPKRY-UHFFFAOYSA-N |
| InChI | InChI=1S/C24H23N5O.CH4O3S/c25-17-24(11-1-2-12-24)19-5-7-20(8-6-19)29-23(30)21-4-3-13-27-22(21)28-16-18-9-14-26-15-10-18;1-5(2,3)4/h3-10,13-15H,1-2,11-12,16H2,(H,27,28)(H,29,30);1H3,(H,2,3,4) |
| PubChem CID | 45139106 |
| Target Point | VEGFR2 |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK |
| Background | Apatinib is a highly selective VEGFR2 inhibitor. |
| Biological Activity | Apatinib 是一种高选择性的 VEGFR2 抑制剂，IC50 为 1 nM。Apatinib也有效抑制Ret，c-Kit 和 c-Src活性，IC50s分别为 13，429 和 530 nM[1]。 |
| IC50 | VEGFR2:1nM [1] |
| Data Literature Source | [1]. Tian S，et al. YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo. Cancer Sci. 2011 Jul;102(7):1374-80 |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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