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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > CarboplatinCAS：41575-94-4
Molecular Formula：C6H12N2O4Pt
Molecular Weight：371.25
Storage：Powder:2-8℃，2 years
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 41575-94-4 |
| Name | Carboplatin |
| Molecular Formula | C6H12N2O4Pt |
| Molecular Weight | 371.25 |
| Solubility | Soluble in Water ≥10mg/mL(This product is not stable in solution, it is recommended that you use it now) |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years |
| Delivery Time | 1-2 Days |
| EC | EINECS 255-446-0 |
| MDL | MFCD00070464 |
| SMILES | O=C1C2(CCC2)C(O[Pt]O1)=O.N.N |
| InChIKey | VSRXQHXAPYXROS-UHFFFAOYSA-N |
| InChI | InChI=1S/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H2;/q;2*-1;+2 |
| PubChem CID | 426756 |
| Target Point | DNA Crosslinker |
| Passage | DNA Damage/DNA Repair |
| Background | Carboplatin is a DNA synthesis inhibitor that binds to DNA, inhibits replication and transcription and induces cell death. It is a derivative of cisplatin. |
| Biological Activity | Carboplatin (NSC 241240) 是一种 DNA 合成 抑制剂，其与 DNA 结合，抑制复制和转录并诱导细胞死亡。Carboplatin (NSC 241240) 是顺铂的衍生物，是一种有效的抗癌剂。[1-4] |
| Data Literature Source | [1]. Natarajan G，et al. Increased DNA-binding activity of cis-1，1-cyclobutanedicarboxylatodiammineplatinum(II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited. Biochem Pharmacol. 1999 Nov 15;58(10):1625-9. [2]. Banerji U，et al. An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models. Cancer Chemother Pharmacol. 2008 Oct;62(5):769-78. [3]. Clark CC，et al. Enhancement of synthetic lethality via combinations of ABT-888，a PARP inhibitor，and carboplatin in vitro and in vivo using BRCA1 and BRCA2 isogenic models. Mol Cancer Ther. 2012 Sep;11(9):1948-58. [4]. Dela Cruz FS，et al. A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma. Genome Med. 2016 Oct 31;8(1):116. |
| Unit | Piece |
| Specification | 50mg 100mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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