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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > Epirubicin HydrochlorideCAS：56390-09-1
Molecular Formula：C27H29NO11·HCl
Molecular Weight：579.98
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Orange to red Solid
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| CAS | 56390-09-1 |
| Name | Epirubicin Hydrochloride |
| Molecular Formula | C27H29NO11·HCl |
| Molecular Weight | 579.98 |
| Solubility | Soluble in Water ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | Orange to red Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Delivery Time | 1-2 Days |
| EC | EINECS 260-145-2 |
| MDL | MFCD00941448 |
| SMILES | O=C(C1=C2C(O)=C3[C@@H](O[C@@]4([H])C[C@H](N)[C@@H](O)[C@H](C)O4)C[C@@](C(CO)=O)(O)CC3=C1O)C5=CC=CC(OC)=C5C2=O.Cl |
| InChIKey | MWWSFMDVAYGXBV-FGBSZODSSA-N |
| InChI | InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22-,27-;/m0./s1 |
| PubChem CID | 65348 |
| Target Point | Topoisomerase |
| Passage | DNA Damage/DNA Repair |
| Background | It is a semi-synthetic L-arabinose derivative of doxorubicin with antitumor activity by inhibiting topoisomerase. Also a Forkhead box protein p3 (Foxp3) inhibitor that inhibits regulatory T cell activity. |
| Biological Activity | Epirubicin hydrochloride 是阿霉素的半合成的 L-阿拉伯糖衍生物，能够抑制 Topoisomerase，起到抗肿瘤的作用。[1-4] |
| Data Literature Source | [1]. Cersosimo RJ， et al. Epirubicin: a review of the pharmacology， clinical activity， and adverse effects of an adriamycin analogue. J Clin Oncol. 1986 Mar; 4 (3) :425-39. [2]. Ozkan， A.， et al. Epirubicin HCl toxicity in human-liver derived hepatoma G2 cells. Pol J Pharmacol， 2004. 56 (4) : p. 435-44. [3]. Bonadonna， G.， et al. Drugs ten years later: epirubicin. Ann Oncol， 1993. 4 (5) : p. 359-69. [4]. Asanuma， F.， et al. Antitumor activity of paclitaxel and epirubicin in human breast carcinoma， R-27. Folia Microbiol (Praha) ， 1998. 43 (5) : p. 473-4. |
| Unit | Piece |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Biodegradable hydrogel from pectin and carboxymethyl cellulose with Silibinin loading for lung tumor therapy
Click to check >>Author：Liping Yin, Wenhao Duan, Yanai Chen, Danyang Chen, Yong Wang, Shuai Guo, Jianglei Qin
IF：8.0250
Publish_to：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
PMID：37268066
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