{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > D4476CAS：301836-43-1
Molecular Formula：C23H18N4O3
Molecular Weight：398.41
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
Qty：
Size：
| CAS | 301836-43-1 |
| Name | D4476 |
| Molecular Formula | C23H18N4O3 |
| Molecular Weight | 398.41 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Delivery Time | 1-2 Days |
| MDL | MFCD09037526 |
| SMILES | O=C(N)C1=CC=C(C=C1)C(N2)=NC(C3=CC=C4OCCOC4=C3)=C2C5=NC=CC=C5 |
| InChIKey | DPDZHVCKYBCJHW-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27) |
| PubChem CID | 6419753 |
| Target Point | Casein Kinase（CK） |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Stem Cells |
| Background | D 4476 is a potent and selective CK1 (casein kinase 1) inhibitor. |
| Biological Activity | D4476 is a potent, selective and cell-permeable inhibitor of casein kinase 1(CK1) with an IC50 value of 0.3 μM in vitro.[1-2] |
| IC50 | CK1: 0.3μM[1] |
| Data Literature Source | [1]. Rena G，et al. D4476，a cell-permeant inhibitor of CK1，suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep. 2004 Jan;5(1):60-5. [2]. J r s M，et al. Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia. J Exp Med. 2014 Apr 7;211(4):605-12. |
| Unit | Piece |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Alfhili MA, et. . Int J Occup Med Environ Health. 2022 Feb 15;35(1):1-11. doi: 10.13075/ijomeh.1896.01814.
Sorry, there is no more information.
Calcium-oxidative stress signaling axis and casein kinase 1α mediate eryptosis and hemolysis elicited by novel p53 agonist inauhzin.
Click to check >>Author：Alfhili MA, Alsalmi E, Aljedai A, Alsughayyir J, A
IF：1.7140
Publish_to：Chemother.
PMID：34410893
Induction of hemolysis and eryptosis by occupational pollutant nickel chloride is mediated through calcium influx and p38 MAP kinase signaling.
Click to check >>Author：Alfhili MA, Alamri HS, Alsughayyir J, Basudan AM.
IF：1.6760
Publish_to：Int J Occup Med Environ Health.
PMID：34524276
Manual Download
