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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Paroxetine HydrochlorideCAS：78246-49-8
Molecular Formula：C19H20FNO3·HCl
Molecular Weight：365.83
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 78246-49-8 |
| Name | Paroxetine Hydrochloride |
| Molecular Formula | C19H20FNO3·HCl |
| Molecular Weight | 365.83 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Delivery Time | 1-2 Days |
| EC | EINECS 616-601-1 |
| MDL | MFCD00797405 |
| SMILES | FC1=CC=C([C@H]2[C@H](COC3=CC=C(OCO4)C4=C3)CNCC2)C=C1.Cl |
| InChIKey | GELRVIPPMNMYGS-RVXRQPKJSA-N |
| InChI | InChI=1S/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;/h1-6,9,14,17,21H,7-8,10-12H2;1H/t14-,17-;/m0./s1 |
| PubChem CID | 62878 |
| Target Point | 5-HT Receptor |
| Passage | GPCR & G Protein;Neuronal Signaling |
| Background | Paroxetine hydrochloride is a potent serotonin reuptake inhibitor that inhibits GRK2 activity. |
| Biological Activity | Paroxetine hydrochloride 是一种抗抑郁药，为高效的五羟色胺再摄取抑制剂，能抑制 GRK2 活性，IC50 值为 14 μM。[1-5] |
| IC50 | 14μM(GRK2)[3] |
| Data Literature Source | [1]. Wang Q，et al. Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis. Sci Rep. 2017 Mar 28;7:45364. [2]. Lassen TR，et al. Effect of paroxetine on left ventricular remodeling in an in vivo rat model of myocardial infarction. Basic Res Cardiol. 2017 May;112(3):26. [3]. Waldschmidt HV，et al. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J Med Chem. 2017 Apr 13;60(7):3052-3069. [4]. Liu RP，et al. Paroxetine ameliorates lipopolysaccharide-induced microglia activation via differential regulation of MAPK signaling. J Neuroinflammation. 2014 Mar 12;11:47. [5]. Zarei M，et al. Paroxetine attenuates the development and existing pain in a rat model of neurophatic pain. Iran Biomed J. 2014;18(2):94-100 |
| Unit | Piece |
| Specification | 50mg 10mM*1mL in DMSO 100mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Gu F , et al. Food Funct. 2020 Jul 1;11(7):6148-6157.
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Lactobacillus casei improves depression-like behavior in chronic unpredictable mild stress-induced rats by the BDNF-TrkB signal pathway and the intestinal microbiota
Click to check >>Author：GuF;WuY;LiuY;DouM;JiangY;LiangH
IF：4.3720
Publish_to：Food Funct
PMID：32578646
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